Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

Abstract Background Alcohol-related liver disease (ALD) is a major cause of chronic diseases. Inflammatory response basic pathological feature ALD. Mucosal-associated invariant T(MAIT) cells are novel population innate immune cells, which may be depleted in various inflammatory However, the changes MAIT cell ALD remains unclear. Results In this study, levels were significantly decreased patients with alcoholic fatty disease, cirrhosis, and mixed cirrhosis (alcoholic + viral). Furthermore, reduction circulating was correlated function cirrhosis. Functional among including increased production IL-17A perforin, reduced TNF-?. Plasma cytokine chemokine quantified using multiple immunoassays ELISA. Serum IL-8 frequency Moreover, no differences observed expression CCR6, CXCR6, PD-1 The prone to apoptosis, promoted by IL-12, IL-18, IL-8. Conclusions Our findings indicate persistent loss during alcohol-related suggest that can promising indicator therapeutic targets